Dimethoxytrityl (DMTCl44)ikemikari ine simba uye inoshanda zvakasiyana-siyana inoshandiswa zvakanyanya muorganic chemistry seboka rinoshanda rinodzivirira, rinobvisa agent, uye hydroxyl inodzivirira agent ye nucleosides uye nucleotides.Yayo yakasarudzika zvivakwa uye akasiyana mashandisiro akaita kuti ive chishandiso chakakosha mumunda wemakemikari synthesis.
DMTCl44, ine kemikari formula C28H23Cl2NO2, inowanzo zivikanwa seDimethoxytrityl chloride.Iyo ine nhamba yeCAS ye40615-36-9 uye inokosheswa zvakanyanya nekuda kwekugona kwayo kuchengetedza nekuita mabasa akasiyana siyana mapoka, nekudaro ichigonesa kuumbwa kwemamorekuru akaomarara nekunyatso uye nekuita.
Chimwe chezvinhu zvakakosha zveDMTCl44kugona kwayo kuchengetedza mapoka ehydroxyl, kunyanya mumanucleosides uye nucleotides.Aya makomisheni anoita basa rakakosha muDNA neRNA synthesis, uye kudzivirira kwavo kwakakosha kuitira kuchengetedza kugadzikana kwavo panguva dzakasiyana siyana shanduko yemakemikari.DMTCl44 inodzivirira zvinobudirira boka rehydroxyl, kudzivirira kuita kusingadiwe uye kubvumira shanduko dzakasarudzwa kuti dziitike kune mamwe mapoka anoshanda.
Uyezve, DMTCl44 inoshanda semumiririri ane hunyanzvi hwekubvisa kana kudzivirira.Inobatsira kubviswa kwemapoka ekudzivirira kana kudiwa kwemakemikari kugadziriswa kwave kuwanikwa.Hunhu uhwu hunonyanya kukosha mukubatanidza nhanho dzakawanda, uko mapoka ekudzivirira anoda kubviswa zvakasarudzwa kuti afumure masayiti anoshanda kuti awedzere shanduko.Kugona kweDMTCl44 kubvisa mapoka ekudzivirira zvakasarudzika uye nemazvo kwasandura ndima ye organic chemistry, zvichiita kuti vatsvakurudzi vaongorore nzira dzakaoma dzekugadzira uye kugadzira mamorekuru matsva ane zviitiko zvebhayoloji zvakawedzerwa.
Maitiro ekushandura anofambiswa neDMTCl44 akawanda.Inoshandiswa zvakanyanya mukugadzirwa kweiyo nucleoside uye nucleotide analogs, ayo akakosha mukuwanikwa kwezvinodhaka nekusimudzira.Nekuvharisa zvine hungwaru mapoka anoshanda, machemist anogona kushandura kudzokororwa kweaya makomisheni kugadzira maanoroji eanoroji ane yakagadziridzwa pharmacological zvimiro.Basa reDMTCl44 sechinhu chinodzivirira hydroxyl rakakosha mumaitiro aya, sezvo richiona kuchengetedzwa kwezvinoda kuitwa biological chiitiko ichibvumira kugadziridzwa kune dzimwe nzvimbo.
DMTCl44zvakare inowana utility mune peptide synthesis, kunyanya mukudzivirira kweamino acids panguva yakasimba-chikamu peptide synthesis.Amino acids ine akawanda reactive anoshanda mapoka ayo anogona kutungamira kune asingadiwe mativi maitiro panguva yekubatanidza.Nekushandisa DMTCl44 seboka rinodzivirira mumiririri, vemakemikari vanogona kudzora reactivity uye nekusarudza kuchengetedza chaiwo mapoka anoshanda, zvichiita kuti kuungana kwakapetwa kwepeptides nekuchena kwakanyanya uye goho.
Pamusoro pekushandisa kwayo mumunda we synthesis, DMTCl44 yakabatsira mukufambira mberi kwakakosha mune organic chemistry.Kushandiswa kwaro seboka rinodzivirira kwakabvumira kuvandudzwa uye kuumbwa kwezvakasiyana zvigadzirwa zvechisikigo, mishonga yemishonga, uye bioactive mamorekuru.Yakavhura nzira nyowani dzekugadzira uye kuumbwa kweinoveli mishonga, catalytic masisitimu, uye zvinoshanda zvinhu.
Mukupedzisa,Dimethoxytrityl (DMTCl44)yabuda sechishandiso chakakosha munyika yeorganic chemistry.Basa rayo seboka rinoshanda rinodzivirira mumiririri, anobvisa mumiriri, uye hydroxyl inodzivirira ajenti yakabatsira zvakanyanya mukufambisira mberi kwekuita kwemakemikari uye kugadzirwa kwemamorekuru matsva.Yayo yakasarudzika zvivakwa uye inoshanda zvakasiyana-siyana inoita kuti ive yakakosha reagent muminda dzakasiyana siyana, kusanganisira mishonga, biochemistry, uye zvinhu sainzi.Sezvo vatsvakurudzi vanoongorora zvakadzika munyika inonakidza yeDMTCl44, ichokwadi kuti mamwe maitiro ekushandura uye mashandisirwo matsva achawanikwa, zvichienderera mberi nekusundira miganhu yeorganic chemistry.
Nguva yekutumira: Sep-26-2023